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dc.contributor.author | Wright, Natalia | - |
dc.contributor.author | Hidalgo, Andrés | - |
dc.contributor.author | Rodríguez-Frade, José Miguel | - |
dc.contributor.author | Soriano, Silvia F. | - |
dc.contributor.author | Mellado, Mario | - |
dc.contributor.author | Parmo-Cabañas, Marisa | - |
dc.contributor.author | Briskin, Michel J. | - |
dc.contributor.author | Teixidó, Joaquín | - |
dc.date.accessioned | 2013-03-19T08:31:23Z | - |
dc.date.available | 2013-03-19T08:31:23Z | - |
dc.date.issued | 2002 | - |
dc.identifier | issn: 0022-1767 | - |
dc.identifier | e-issn: 1550-6606 | - |
dc.identifier.citation | Journal of Immunology 168(10):5268-5277(2002) | - |
dc.identifier.uri | http://hdl.handle.net/10261/72342 | - |
dc.description.abstract | The interaction between the integrin α4β7 and its ligand, mucosal addressin cell adhesion molecule-1, on high endothelial venules represents a key adhesion event during lymphocyte homing to secondary lymphoid tissue. Stromal cell-derived factor-1α (SDF-1α) is a chemokine that attracts T and B lymphocytes and has been hypothesized to be involved in lymphocyte homing. In this work we show that α4β7-mediated adhesion of CD4+ T lymphocytes and the RPMI 8866 cell line to mucosal addressin cell adhesion molecule-1 was up-regulated by SDF-1α in both static adhesion and cell detachment under shear stress assays. Both naive and memory phenotype CD4+ T cells were targets of SDF-1α-triggered increased adhesion. In addition, SDF-1α augmented α4β7-dependent adhesion of RPMI 8866 cells to connecting segment-1 of fibronectin. While pertussis toxin totally blocked chemotaxis of CD4+ and RPMI 8866 cells to SDF-1α, enhanced α4β7-dependent adhesion triggered by this chemokine was partially inhibited, indicating the participation of Gαi-dependent as well as Gαi-independent signaling. Accordingly, we show that SDF-1α induced a rapid and transient association between its receptor CXCR4 and Gαi, whereas association of pertussis toxin-insensitive Gα13 with CXCR4 was slower and of a lesser extent. SDF-1α also activated the small GTPases RhoA and Rac1, and inhibition of RhoA activation reduced the up-regulation of α4β7-mediated lymphocyte adhesion in response to SDF-1α, suggesting that activation of RhoA could play an important role in the enhanced adhesion. These data indicate that up-regulation by SDF-1α of lymphocyte adhesion mediated by α4β7 could contribute to lymphocyte homing to secondary lymphoid tissues. | - |
dc.description.sponsorship | This work was supported by Grant SAF99-0057 from Ministerio de Ciencia y Tecnología. N.W. is the recipient of a predoctoral fellowship from the Comunidad de Madrid | - |
dc.language.iso | eng | - |
dc.publisher | American Association of Immunologists | - |
dc.rights | closedAccess | - |
dc.title | The chemokine stromal cell-derived factor-1α modulates α4β7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin | - |
dc.type | artículo | - |
dc.date.updated | 2013-03-19T08:31:23Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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