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An insight into the proteome of the saliva of the argasid tick Ornithodoros moubata reveals important differences in saliva protein composition between the sexes

AuthorsDíaz Martín, Verónica ; Manzano Román, Raúl ; Valero, Luz; Oleaga, Ana ; Encinas Grandes, Antonio; Pérez Sánchez, Ricardo
KeywordsOrnithodoros moubata
Protein equalization
Issue Date27-Mar-2013
CitationJournal of Proteomics 80: 216-235 (2013)
AbstractTick saliva contains pharmacologically active molecules that allow these parasites to obtain a blood meal from the host and facilitate host infection by tick-borne pathogens. Recent transcriptomic and proteomic analyses of the salivary glands of several tick species have provided data sets that are invaluable for a better understanding of tick sialomes and tick– host–pathogen relationships. Here we performed a proteomic study of the saliva from the argasid tick Ornithodoros moubata. Saliva samples from female and male specimens were analyzed separately by LC–MS/MS before and after their equalization to facilitate the identification of the less abundant proteins. We report the array of 193 proteins identified in the saliva of O. moubata showing: (i) the broad and complex composition of the saliva of this tick, in good agreement with the complexity of the argasid and ixodid sialomes described previously; (ii) a notable difference in the saliva proteomes of females and males, since only 10 of the proteins identified appeared to be shared by both sexes; and (iii) the presence in the salivary fluid of a wide range of proteins known to be housekeeping/intracellular, which could be secreted in unconventional ways, including exosome secretion.
Description26 páginas, 3 tablas, 6 figuras. -- The definitive version is available at http://www.elsevier.com
Publisher version (URL)http://dx.doi.org/10.1016/j.jprot.2013.01.015
Appears in Collections:(IRNASA) Artículos
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