English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/72241
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Opioids trigger α5β1 integrin-mediated monocyte adhesion

AuthorsPello, Oscar M.; Duthey, Béatrice; García-Bernal, David ; Rodríguez-Frade, José Miguel; Stein, Jens V.; Teixidó, Joaquín ; Martínez-Alonso, Carlos; Mellado, Mario
Issue Date1-Feb-2006
PublisherAmerican Association of Immunologists
CitationJournal of Immunology 176(3):1675-1685(2006)
AbstractInflammatory reactions involve a network of chemical and molecular signals that initiate and maintain host response. In inflamed tissue, immune system cells generate opioid peptides that contribute to potent analgesia by acting on specific peripheral sensory neurons. In this study, we show that opioids also modulate immune cell function in vitro and in vivo. By binding to its specific receptor, the opioid receptor-specific ligand DPDPE triggers monocyte adhesion. Integrins have a key role in this process, as adhesion is abrogated in cells treated with specific neutralizing anti-α5β1 integrin mAb. We found that DPDPE-triggered monocyte adhesion requires PI3Kγ activation and involves Src kinases, the guanine nucleotide exchange factor Vav-1, and the small GTPase Rac1. DPDPE also induces adhesion of pertussis toxin-treated cells, indicating involvement of G proteins other than Gi. These data show that opioids have important implications in regulating leukocyte trafficking, adding a new function to their known effects as immune response modulators
Description11 páginas, 7 figuras -- PAGS nros. 1675-1685
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdf21,67 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.