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Título: | Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: Cellular and molecular mechanisms |
Autor: | Méndez, Pablo ; Wandosell, Francisco CSIC ORCID ; García-Segura, Luis M. CSIC ORCID | Fecha de publicación: | 2006 | Editor: | Academic Press | Citación: | Frontiers in Neuroendocrinology 27: 391-403 (2006) | Resumen: | Accumulating evidence suggests that insulin-like growth factor-I (IGF-I) and estradiol interact to regulate neural function. In this review, we focus on the cellular and molecular mechanisms involved in this interaction. The expression of estrogen receptors (ERs) and IGF-I receptor is cross-regulated in the central nervous system and many neurons and astrocytes coexpress both receptors. Furthermore, estradiol activates IGF-I receptor and its intracellular signaling. This effect may involve classical ERs since recent findings suggest that ERα may affect IGF-I actions in the brain by a direct interaction with some of the components of IGF-I signaling. In turn, IGF-I may regulate ER transcriptional activity in neuronal cells. In conclusion, ERs appear to be part of the signaling mechanism of IGF-I, and IGF-I receptor part of the mechanism of estradiol signaling in the nervous system. © 2006 Elsevier Inc. All rights reserved. | URI: | http://hdl.handle.net/10261/71850 | DOI: | 10.1016/j.yfrne.2006.09.001 | Identificadores: | doi: 10.1016/j.yfrne.2006.09.001 issn: 0091-3022 |
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