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Snail1 controls TGFB responsiveness and differentiation of mesenchymal stem cells

AuthorsBatlle, R.; Barderas, Rodrigo ; Bonilla, Félix; Casal, J. Ignacio ; García de Herreros, Antonio
Mesenchymal stem cells
Issue Date2013
PublisherNature Publishing Group
CitationOncogene 32(28): 3381-3389 (2013) advance online publication
AbstractThe Snail1 transcriptional repressor plays a key role in triggering epithelial-to-mesenchymal transition. Although Snail1 is widely expressed in early development, in adult animals it is limited to a subset of mesenchymal cells where it has a largely unknown function. Using a mouse model with inducible depletion of Snail1, here we demonstrate that Snail1 is required to maintain mesenchymal stem cells (MSCs). This effect is associated to the responsiveness to transforming growth factor (TGF)-β1 that shows a strong Snail1 dependence. Snail1 depletion in conditional knockout adult animals causes a significant decrease in the number of bone marrow-derived MSCs. In culture, Snail1-deficient MSCs prematurely differentiate to osteoblasts or adipocytes and, in contrast to controls, are resistant to the TGF-β1-induced differentiation block. These results demonstrate a new role for Snail1 in TGF-β response and MSC maintenance
DescriptionPMC3494751.-- et al.
Publisher version (URL)http://dx.doi.org/10.1038/onc.2012.342
Appears in Collections:(CIB) Artículos
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