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Title

Passive smoking alters circulating naïve/memory lymphocyte T-cell subpopulations in children

AuthorsVardavas, C. I.; Plada, M.; Tzatzarakis, M.; Marcos, Ascensión CSIC ORCID; Wärnberg, Julia CSIC ORCID; Gómez-Martínez, Sonia CSIC ORCID; Breidenassel, Christina; González-Gross, Marcela CSIC ORCID; Tsatsakis, A. M.; Saris, W. H.; Moreno, Luis A.; Kafatos, Anthony
Issue Date2010
PublisherBlackwell Publishing
CitationPediatric Allergy and Immunology 21: 1171- 1178 (2010)
AbstractWhile it has been indicated that exposure to second-hand smoke (SHS) can cause a local in vivo response, limited evidence exists on its possible systemic effects from population-based levels of exposure. We investigated into a possible systemic response in the immune parameters and lymphocyte subsets, i.e. B cell (CD19+), T cell (CD4+CD45RO+, CD4+CD45RA+, CD3+CD45RO+, CD3+CD45RA+) and natural killer (CD3+CD16CD56+) lymphocyte subsets relative to exposure to SHS. Blood was drawn from healthy, verified non-smoker, adolescent subjects (n = 68, mean age 14.2) and analysed for cotinine, antioxidants and lymphocyte immunophenotyping. SHS exposure was assessed using serum cotinine. Biomarker quantified exposure to SHS was correlated with a linear dose-response reduction in the percentages of memory CD4+CD45RO+ (p = 0.005) and CD3+CD45RO+ T-cell subsets (p = 0.005 and p = 0.003, respectively) and a linear increase in the percentage of naïve CD4+CD45RA+ and CD3+CD45RA+ T-cell subsets (p = 0.006 and p = 0.003, respectively). Additionally, higher exposure to SHS was associated with a higher CD4+CD45RA+ count (532 vs. 409 cells/ml, p = 0.017). Moreover, after controlling for age, gender, body mass index and plasma antioxidants, SHS exposure was found to be associated with the percentage of circulating naïve and memory CD4+ and CD3+ T-cell subpopulations, as revealed through a linear regression analysis. These findings indicate a systemic immunological response in healthy adolescents exposed to population-based levels of SHS exposure and imply an additional biological pathway for the interaction between exposure to SHS and its adverse effects on human health. © 2010 John Wiley & Sons A/S.
URIhttp://hdl.handle.net/10261/71732
DOI10.1111/j.1399-3038.2010.01039.x
Identifiersdoi: 10.1111/j.1399-3038.2010.01039.x
issn: 0905-6157
Appears in Collections:(ICTAN) Artículos




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