Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/71674
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | General redox environment and carotid body chemoreceptor function |
Autor: | Agapito, Teresa CSIC ORCID; Sanz-Alfayate, Gloria; Gómez-Niño, A. CSIC ORCID; González, Constancio CSIC; Obeso, Ana CSIC ORCID | Fecha de publicación: | 2009 | Editor: | American Physiological Society | Citación: | American Journal of Physiology - Cell Physiology 296(3): C620-C631 (2009) | Resumen: | Carotid body (CB) chemoreceptor cells detect physiological levels of hypoxia and generate a hyperventilation, homeostatic in nature, aimed to minimize the deleterious effects of hypoxia. Intimate mechanisms involved in oxygen sensing in chemoreceptor cells remain largely unknown, but reactive oxygen species (ROS) had been proposed as mediators of this process. We have determined glutathione levels and calculated glutathione redox potential (E GSH; indicator of the general redox environment of cells) in rat diaphragms incubated in the presence of oxidizing agents of two types: nonpermeating and permeating through cell membranes; in the latter group, unspecific oxidants and inhibitors of ROS-disposing enzymes were used. Selected concentrations of oxidizing agents were tested for their ability to modify the normoxic and hypoxic activity of chemoreceptor cells measured in vitro as their rate of release of neurotransmitters. Results evidence variable relationships between EGSH and the activity of chemoreceptor cells. The independence of chemoreceptor cell activity from the EGSH would imply that the ability of the CB to play its homeostatic role is largely preserved in any pathological or toxicological contingency causing oxidative stress. Consistent with this suggestion, it was also found that CB-mediated hypoxic hyperventilation was not altered by treatment of intact animals with agents that markedly decreased the EGSH in all tissues assayed. Copyright © 2009 the American Physiological Society. | URI: | http://hdl.handle.net/10261/71674 | DOI: | 10.1152/ajpcell.00542.2008 | Identificadores: | doi: 10.1152/ajpcell.00542.2008 issn: 0363-6143 e-issn: 1522-1563 |
Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
19
checked on 30-mar-2024
WEB OF SCIENCETM
Citations
17
checked on 17-feb-2024
Page view(s)
231
checked on 19-abr-2024
Download(s)
77
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.