English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/71546
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Sonic hedgehog guides post-crossing commissural axons both directly and indirectly by regulating Wnt activity

AuthorsDomanitskaya, E.; Wacker, A.; Mauti, O.; Baeriswyl, T.; Esteve, Pilar ; Bovolenta, Paola ; Stoeckli, Esther T.
Issue Date2010
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 30: 11167-11176 (2010)
AbstractAfter midline crossing, axons of dorsolateral commissural neurons turn rostrally into the longitudinal axis of the spinal cord. In mouse, the graded distribution of Wnt4 attracts post-crossing axons rostrally. In contrast, in the chicken embryo, the graded distribution of Sonic hedgehog (Shh) guides post-crossing axons by a repulsive mechanism mediated by hedgehog-interacting protein. Based on these observations, we tested for a possible cooperation between the two types of morphogens. Indeed, we found that Wnts also act as axon guidance cues in the chicken spinal cord. However, in contrast to the mouse, Wnt transcription did not differ along the anteroposterior axis of the spinal cord. Rather, Wnt function was regulated by a gradient of the Wnt antagonist Sfrp1 (Secreted frizzled-related protein 1) that in turn was shaped by the Shh gradient. Thus, Shh affects post-crossing axon guidance both directly and indirectly by regulating Wnt function. Copyright © 2010 the authors.
URIhttp://hdl.handle.net/10261/71546
DOI10.1523/JNEUROSCI.1488-10.2010
Identifiersdoi: 10.1523/JNEUROSCI.1488-10.2010
issn: 0270-6474
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
Bovolenta,2010,JNeuroscience,30,11167-.pdf2,85 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.