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Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex

AuthorsPichardo, C.; Conejo, María del Carmen; Docobo-Pérez, Fernando ; Velasco, C.; López-Rojas, Rafael; García, I.; Pachón-Ibáñez, M. E.; Rodríguez-Martínez, José-Manuel; Pachón, Jerónimo ; Pascual, Álvaro
Issue Date2011
CitationEuropean Journal of Clinical Microbiology and Infectious Diseases 30(2): 289-291 (2011)
AbstractZinc eluted from siliconized latex (SL) increases resistance of Pseudomonas aeruginosa to imipenem in vitro. A foreign body peritonitis model was used to evaluate the activity of imipenem using SL or silicone (S) implants. No differences were observed in mortality, positive blood cultures and tissue bacterial counts between SL and S implants. Implant-associated counts, however, were significantly higher in the SL group. It is concluded that SL decreases the activity of imipenem against P. aeruginosa.
Identifiersdoi: 10.1007/s10096-010-1084-y
issn: 0934-9723
Appears in Collections:(IBFG) Artículos
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