English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/71004
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Dense and overlapping innervation of pyramidal neurons by chandelier cells

AuthorsInan, M.; Blázquez-Llorca, Lidia ; Merchán-Pérez, Ángel ; Anderson, Stewart A.; DeFelipe, Javier ; Yuste, Rafael
Issue Date2013
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 33: 1907- 1914 (2013)
AbstractChandelier (or axo-axonic) cells are a distinct group of GABAergic interneurons that innervate the axon initial segments of pyramidal cells and thus could have an important role controlling the activity of cortical circuits. To understand their connectivity, we labeled upper layers chandelier cells (ChCs) from mouse neocortex with a genetic strategy and studied how their axons contact local populations of pyramidal neurons, using immunohistochemical detection of axon initial segments. We studied ChCs located in the border of layers 1 and 2 from primary somatosensory cortex and found that practically all ChC axon terminals contact axon initial segments, with an average of three to five boutons per cartridge. By measuring the number of putative GABAergic synapses in initial segments, we estimate that each pyramidal neuron is innervated, on average, by four ChCs. Additionally, each individual ChC contacts 35-50% of pyramidal neurons within the areas traversed by its axonal arbor, with pockets of very high innervation density. Finally, ChCs have similar innervation patterns at different postnatal ages (P18-P90), with only relatively small lateral expansions of their arbor and increases in the total number of their cartridges during the developmental period analyzed. We conclude that ChCs innervate neighboring pyramidal neurons in a dense and overlapping manner, a connectivity pattern that could enable ChCs to exert a widespread influence on their local circuits. © 2013 the authors.
URIhttp://hdl.handle.net/10261/71004
DOI10.1523/JNEUROSCI.4049-12.2013
Identifiersdoi: 10.1523/JNEUROSCI.4049-12.2013
issn: 0270-6474
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
DeFelipe,2013,JNeuroscience,33,1907-.pdf999,48 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.