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Expression of the vaccinia related kinase (VRK) gene family of p53 regulators in murine hematopoietic development

AutorVega, Francisco M.; Gonzalo, P.; Gaspar, M. L.; Lazo, Pedro A.
Palabras claveVRK
Fecha de publicación2003
CitaciónFEBS Letters 544 (2003) 176-180
ResumenThe vaccinia-related kinase (VRK) proteins are a new group of three Ser-Thr kinases in the human kinome. VRK proteins are upstream regulators of several transcription factors. VRK1phosphorylates p53 in Thr-18 within the region of binding to mdm2 preventing their interaction. The tissue distribution of three genes is still largely unknown. In the present report the expression of these genes was analyzed during murine hematopoietic development. The three genes are expressed in fetal liver and peripheral blood, with higher levels between days 11.5 and 13.5, a time when there is a massive expansion of liver cells, and thereafter their expression falls signi¢cantly. VRK genes are expressed, particularly at mid-gestation, in embryo thymus and spleen, but in adult thymus and spleen their levels are very low. VRK2 is expressed at lower levels than VRK1and VRK3 in the mouse embryo. VRK genes play a role during embryonic development of hematopoiesis
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