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Título : Cell envelope changes in Bifidobacterium animalis ssp. lactis as a response to bile
Autor : Ruíz García, Lorena ; Sánchez García, Borja ; Ruas-Madiedo, Patricia ; González de los Reyes-Gavilán, Clara ; Margolles Barros, Abelardo
Palabras clave : Bifidobacterias animales
Bilis
Ácidos grasos
Fecha de publicación : 25-jul-2007
Editor: Federation of European Microbiological Societies
Blackwell Publishing
Citación : FEMS Microbiology Letters 274 (2), 316-322 (2007)
Resumen: Bifidobacterium animalis ssp. lactis is a probiotic frequently used as adjunct culture in fermented dairy products. In order to ensure its proper function at the intestinal level, this bacterium has to be tolerant to physiological concentrations of bile. This study examined the influence of bile on the fatty acid composition and the membrane characteristics of B. animalis IPLA 4549 and its mutant with acquired resistance to bile, B. animalis 4549dOx. Bile adaptation triggers in B. animalis 4549dOx a decrease in membrane fluidity and in the protein : phospholipid ratio, as well as a shift in the fatty acid composition of the cell. Remarkably, the presence of bile in the growth medium induced similar changes in both B. animalis cells. Furthermore, transmission electron microscopy analysis showed that bile promotes a severe distortion of the cell surface. This study provides new insights of the action of bile on the cell envelope of bifidobacteria
URI : http://hdl.handle.net/10261/7038
DOI: 10.1111/j.1574-6968.2007.00854.x
ISSN: 1574-6968 (Online)
0378-1097 (Print)
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