English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/7017
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 14 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types

Autor Yunta, M.; Oliva, José Luis; Barcia, R.; Lazo, Pedro A.
Palabras clave CD53
JNK
Tetraspanin
Signal transduction
Fecha de publicación 2002
EditorWiley-Blackwell
Citación European Journal of Biochemistry 269(3): 1012-1021 (2002)
ResumenTheCD53 antigen is amember of the tetraspaninmembrane protein family that is expressed in the lymphoid-myeloid lineage.We have studied the implication of CD53 antigen in signal transduction by determining the effect of its ligation on the c-Jun N-terminal kinase (JNK) in different cell types. Ligation of the rat or human CD53 antigen induces a three- to fourfold transient activation of JNKactivity that peaks at 3±5 min.The effect was detected by assaying the endogenous or exogenous (transfected) JNKactivity. The JNK response was detected in IR938F cells, a rat B-cell lymphoma, and in Jurkat cells derived from a human T-cell lymphoma. This JNK activation was not mediated by the vav oncogene, and CD53 does not cooperate with CD3 for vav activation. Asimilar JNKactivation was also detected in a human renal carcinoma cell line that was transiently transfected with the human CD53 cDNA to mimic the CD53 ectopic expression in carcinomas. In stable CD53-transfected cells it stimulated Jun-dependent transcriptional activity. We conclude that parts of the cell responses modulated by the CD53 are mediated by JNK activation, and this activation is independent of the different protein interactions that the CD53 protein has on speci®c cell types.
URI http://hdl.handle.net/10261/7017
DOI10.1046/j.0014-2956.2001.02741.x
ISSN0014-2956
Aparece en las colecciones: (IBMCC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.