English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/7016
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Genomic organization, chromosomal localization, alternative splicing,and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes

AutorLazo, Pedro A. ; Nadal, Marga; Ferrer, Milagros; Area, Estela; Hernández-Torres, Javier; Nabokina, S. M.; Mollinedo, Faustino ; Estivill, Xavier
Palabras claveSNAP23
Fecha de publicación6-mar-2001
EditorSpringer
CitaciónHuman Genetics 108(3): 211–215 (2001)
ResumenSynaptosome-associated protein-23 (SNAP23) is a component of the cellular mechanism required for specific membrane fusion and targetting of intracellular vesicles. We have cloned the full-length human cDNA and the SNAP23 gene. The SNAP23 gene has eight exons, with the initiation codon located in exon 2, and maps to the human chromosome 15q21–22 region. The human SNAP23 gene can generate two types of message, the full-length message (SNAP23A) and a shorter message (SNAP23B). The latter is the result of alternative splicing where exon 5 is joined to exon 7 and the skipping of exon 6; it thus lacks a region that is required for non-specific binding to plasma membranes. The two isoforms, expressed as fusion proteins with glutathione-S-transferase, interact in vitro with human syntaxin 6, thus retaining the specific protein interaction required for membrane fusion. Alterations in the SNAP23 gene might be involved in neurological and other diseases with defects in vesicle-membrane fusion processes that map to 15q15–21.
Descripción5 pages, 2 figures.-- PMID: 11354632 [PubMed].-- Related research antibodies (Cytoskeleton antibodies, anti-SNAP23, anti-syntaxin 6 and anti-glutathione-S-transferase) available at http://www.antibodies-online.com/
Versión del editorhttp://dx.doi.org/10.1007/s004390100480
URIhttp://hdl.handle.net/10261/7016
DOI10.1007/s004390100480
ISSN0340-6717
E-ISSN1432-1203
Aparece en las colecciones: (IBMCC) Artículos
(CNB) Artículos
(IBGM) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.