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Biological effects of group IIA secreted phosholipase A2

AuthorsFuentes, Lucía ; Hernández, Marita ; Nieto, María Luisa ; Sánchez Crespo, Mariano
Issue Date2002
CitationFEBS Letters 531(1): 7-11 (2002)
AbstractGroup IIA secreted phospholipase A2 (sPLA2-IIA) is the most abundant element in human tissues of a large family of low molecular weight phospholipases A2, which shows properties different from those displayed by the cytosolic phospholipase A2 involved in the release of arachidonic acid. sPLA2-IIA behaves as a ligand for a group of receptors inside the C-type multilectin mannose receptor family and also interacts with heparan sulfate proteoglycans such as glypican, the dermatan/chondroitin sulfate-rich decorin, and the chondroitin sulfate-rich versican, thus being able to internalize to specific compartments within the cell and producing biological responses. This review provides a short summary of the biological actions of sPLA2-IIA on intracellular signaling pathways. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Identifiersdoi: 10.1016/S0014-5793(02)03401-4
issn: 0014-5793
Appears in Collections:(IBGM) Artículos
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