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dc.contributor.authorBriales, Alejandra-
dc.contributor.authorRodríguez-Martínez, José-Manuel-
dc.contributor.authorVelasco, C.-
dc.contributor.authorDíaz-de-Alba, Paula-
dc.contributor.authorDomínguez-Herrera, Juan-
dc.contributor.authorPachón, Jerónimo-
dc.contributor.authorPascual, Álvaro-
dc.identifierdoi: 10.1128/AAC.00927-10-
dc.identifierissn: 0066-4804-
dc.identifier.citationAntimicrobial Agents and Chemotherapy 55(3): 1266-1269 (2011)-
dc.description.abstractThis article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants. Copyright © 2011, American Society for Microbiology. All Rights Reserved.-
dc.description.sponsorshipThis work was supported by the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (project PI060580) and the Consejería de Innovacio´n Ciencia y Empresa, Junta de Andalucía (P07-CTS-02908), Spain. It was partly supported by the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III-FEDER, Spanish Network for Research in Infectious Diseases (REIPI RD06/0008). A.B. was funded by a predoctoral grant from the Instituto de Salud Carlos III (PFIS), Spain.-
dc.publisherAmerican Society for Microbiology-
dc.titleIn vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC-
dc.description.versionPeer Reviewed-
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