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dc.contributor.authorCosta, Alzenira-
dc.contributor.authorGao, Lin-
dc.contributor.authorCáceres-Redondo, María T.-
dc.contributor.authorCarballo, Manuel-
dc.contributor.authorDíaz-Martín, J.-
dc.contributor.authorGómez-Garre, Pilar-
dc.contributor.authorSobrino, F.-
dc.contributor.authorLucas, Miguel-
dc.contributor.authorLópez-Barneo, José-
dc.contributor.authorMir, Pablo-
dc.contributor.authorPindado, Elizabeth-
dc.identifierdoi: 10.1016/j.parkreldis.2010.12.013-
dc.identifierissn: 1353-8020-
dc.identifier.citationParkinsonism and Related Disorders 17(4): 281-284 (2011)-
dc.description.abstract[Background]It is debatable whether the size of triplet repeats of the fragile X mental retardation genes FMR1 and FMR2 (found at the FRAXA and FRAXE loci) is associated with Parkinson's disease (PD). The aims of the current study were to investigate the relationship between these genes and PD and to determine whether these genes affected clinical manifestations of PD.-
dc.description.abstract[Methods] We recruited 206 PD patients and 227 control subjects from southern Spain. All subjects were screened for the size of CGG and CCG repeats at the FRAXA and FRAXE loci, respectively. Clinical features of each patient were examined in detail to study possible association between these features and genotype.-
dc.description.abstract[Results] Frequencies of FRAXA and FRAXE intermediate alleles were similar between PD and control groups. Clinical characteristics in PD patients, including severity of the disease, motor and non-motor symptoms, and motor complications and fluctuations were not affected by intermediate alleles at either locus. Two patients carrying FRAXA premutation alleles were identified showing clinical manifestations indistinguishable from idiopathic PD.-
dc.description.abstract[Conclusions] FRAXA and FRAXE intermediate alleles do not seem to affect the risk for PD or modify clinical features in PD patients. © 2010 Elsevier Ltd.-
dc.description.sponsorshipThis work was supported by grants from the Ministerio de Educación y Ciencia de España (PI081332: AC, EP; SAF2007-60700: FC, PG-G, JD-M, PM; SAF2006/08311: JDM, LG, JLB), Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía (CVI-02526: FC, MC, PG-G, LG, JD-M, PM, CTS-3560: LG; CVI-03550: AC, EP, FS), Consejería de Salud de la Junta de Andalucía (PI-0377/2007: FC, PG-G, PM; PI-0116/2007: AC, FC, FJP, ML, PM, EP), Sociedad Andaluza de Neurología (FC, MC, PM), Fundación Marcelino Botín (JD-M, LG, JLB), and Fundación Juan March (JLB). LG (CP03/000047) and PG-G (CP08/00174) were also supported by Instituto de Salud Carlos III. AC was supported by a fellowship from Hospital Universitario Virgen Macarena.-
dc.titleIntermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease-
dc.description.versionPeer Reviewed-
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