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Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: The AFINOS Study

AuthorsMartínez Gómez, D. ; Eisenmann, J. C.; Wärnberg, Julia; Gómez Martínez, Sonia ; Veses, Ana M. ; Veiga, Óscar; Marcos, Ascensión
Issue Date2010
PublisherNature Publishing Group
CitationInternational Journal of Obesity 34: 1501- 1507 (2010)
AbstractObjective:To examine the independent associations of objectively measured physical activity (PA), cardiorespiratory fitness (CRF) and fatness with low-grade inflammatory markers in adolescents.Design:Cross-sectional study in Spain.Subjects:A sample of 192 adolescents aged 13-17 years.Measurements:PA was assessed with an accelerometer for 7 days. A 20-m shuttle-run test was used to assess CRF. Skinfold thicknesses at six sites and WCs were measured. BMI was calculated from measured height and weight. C-reactive protein (CRP), interleukin-6 (IL-6) and complement factors C3 and C4 were assayed. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from glucose and insulin. Regression analysis adjusted for potential confounders and HOMA-IR was used to determine the associations between PA, CRF and fatness with low-grade inflammatory markers.Results:Total PA, vigorous PA and MVPA were positively associated with CRF (r=-0.25-0.48), whereas vigorous PA was negatively associated with skinfolds (r=0.27). CRF was inversely associated with fatness, (r=0.30 to 0.48). CRF and fatness were inversely and positively associated with HOMA-IR (r=0.16 and 0.21, respectively). PA variables were not independently associated with inflammatory markers. CRF and fatness were inversely and positively associated with CRP, C3 and C4, respectively. Only body fat explained a relevant amount of the variance of the model in CRP (4%) and C4 (19%), whereas CRP and body fat jointly explained the variance in C3 (25%). All these observations were independent of HOMA-IR.Conclusions:These findings support the key role of CRF and fatness on low-grade inflammation, as well as the possible indirect role of habitual PA through CRF and body fat in adolescents. © 2010 Macmillan Publishers Limited All rights reserved.
Identifiersdoi: 10.1038/ijo.2010.114
issn: 0307-0565
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