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Título: | Improved viral suppression after treatment optimization in HIV-infected patients with persistent low-level Viremia |
Autor: | McConnell, Michael J.; Mier-Mota, Julián; Flor-Parra, Fernando; Martínez Fernández, F. J.; López-Cortés, Luis F. CSIC ORCID; Viciana, Pompeyo CSIC; Fernández-Cuenca, Felipe CSIC ORCID CVN; Pérez-Romero, Pilar CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Lippincott Williams & Wilkins | Citación: | Journal of Acquired Immune Deficiency Syndromes 58(5): 446-449 (2011) | Resumen: | Optimizing treatment for patients with persistent low-level viremia is complicated because most genotyping tests are validated for viral loads >1000 copies per milliliter. In this study, genotypes of 92 treatment-experienced patients with persistent low-level viremia were determined using an in-house assay. Based on the resistance profiles obtained from genotyping and patient pharmacologic history, patients were either maintained on their antiviral regimen (n = 51) or received an optimized regimen (n = 41). In the group receiving optimized treatment, undetectable viral loads were achieved in 73.2% at 6 months and at 90.2% at 1 year, indicating that treatment guided by genotyping of patients with low-level viremia is effective in achieving viral suppression. | URI: | http://hdl.handle.net/10261/68460 | DOI: | 10.1097/QAI.0b013e3182364513 | Identificadores: | doi: 10.1097/QAI.0b013e3182364513 issn: 1525-4135 |
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