Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/67592
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice

AutorVelasco-Hernández, Talia CSIC ORCID; Vicente-Dueñas, Carolina CSIC ORCID; Sánchez García, Isidro CSIC ORCID ; Martín-Zanca, Dionisio CSIC ORCID
Fecha de publicación2013
EditorLandes Bioscience
CitaciónCell Cycle 12(1): 122-132 (2013)
ResumenLoss of p53 function is a common feature of human cancers and it is required for differentiated tumor cell maintenance; however, it is not known whether sustained inactivation of the p53 pathway is needed for cancer stem cell persistence. Chronic myeloid leukemia (CML) is caused by a chromosome translocation that generates the BCRABL oncogene encoding a constitutively active protein tyrosine kinase. The disease originates in a hematopoietic stem cell and is maintained by leukemic stem cells (LSCs). Treatment with specific tyrosine kinase inhibitors does not eliminate LSCs because they do not depend on the oncogene for survival. We have combined a switchable p53 knock-in mouse model, p53KI/KI, with the well-characterized Sca1-BCRABLp210 CML transgenic model, to show that transient restoration of p53 slows disease progression and significantly extends the survival of leukemic animals, being the mechanism responsible for this effect, apoptotic death of primitive leukemia cells. In agreement with these in vivo findings, in vitro assays show that restoring p53 reduces hematopoietic colony formation by cells of leukemic animals. These results suggest that reestablishing p53 function may be a therapeutic strategy for the eradication of leukemic stem cells and to prevent disease progression. © 2013 Landes Bioscience.
URIhttp://hdl.handle.net/10261/67592
DOI10.4161/cc.23031
Identificadoresissn: 1538-4101
e-issn: 1551-4005
Aparece en las colecciones: (IBMCC) Artículos
(IBFG) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

6
checked on 29-mar-2024

SCOPUSTM   
Citations

19
checked on 22-mar-2024

WEB OF SCIENCETM
Citations

15
checked on 29-feb-2024

Page view(s)

325
checked on 29-mar-2024

Download(s)

95
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.