Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/67592
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice |
Autor: | Velasco-Hernández, Talia CSIC ORCID; Vicente-Dueñas, Carolina CSIC ORCID; Sánchez García, Isidro CSIC ORCID ; Martín-Zanca, Dionisio CSIC ORCID | Fecha de publicación: | 2013 | Editor: | Landes Bioscience | Citación: | Cell Cycle 12(1): 122-132 (2013) | Resumen: | Loss of p53 function is a common feature of human cancers and it is required for differentiated tumor cell maintenance; however, it is not known whether sustained inactivation of the p53 pathway is needed for cancer stem cell persistence. Chronic myeloid leukemia (CML) is caused by a chromosome translocation that generates the BCRABL oncogene encoding a constitutively active protein tyrosine kinase. The disease originates in a hematopoietic stem cell and is maintained by leukemic stem cells (LSCs). Treatment with specific tyrosine kinase inhibitors does not eliminate LSCs because they do not depend on the oncogene for survival. We have combined a switchable p53 knock-in mouse model, p53KI/KI, with the well-characterized Sca1-BCRABLp210 CML transgenic model, to show that transient restoration of p53 slows disease progression and significantly extends the survival of leukemic animals, being the mechanism responsible for this effect, apoptotic death of primitive leukemia cells. In agreement with these in vivo findings, in vitro assays show that restoring p53 reduces hematopoietic colony formation by cells of leukemic animals. These results suggest that reestablishing p53 function may be a therapeutic strategy for the eradication of leukemic stem cells and to prevent disease progression. © 2013 Landes Bioscience. | URI: | http://hdl.handle.net/10261/67592 | DOI: | 10.4161/cc.23031 | Identificadores: | issn: 1538-4101 e-issn: 1551-4005 |
Aparece en las colecciones: | (IBMCC) Artículos (IBFG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
6
checked on 29-mar-2024
SCOPUSTM
Citations
19
checked on 22-mar-2024
WEB OF SCIENCETM
Citations
15
checked on 29-feb-2024
Page view(s)
325
checked on 29-mar-2024
Download(s)
95
checked on 29-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.