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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Torres, Concepción | - |
dc.contributor.author | Aránguez, Isabel | - |
dc.contributor.author | Rubio, Nazario | - |
dc.date.accessioned | 2013-02-27T12:41:16Z | - |
dc.date.available | 2013-02-27T12:41:16Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Immunology 86: 250-255 (1995) | - |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.uri | http://hdl.handle.net/10261/67503 | - |
dc.description.abstract | Interferon-γ (IFN-γ) is a cytokine known to exert an important immunological role on astrocytes and oligodendrocytes. As a receptor for IFN-γ has been demonstrated on murine astrocytes, we have searched for a specific receptor on the cell surface of pure mouse oligodendrocytes maintained in tissue culture. Using recombinant murine IFN-γ labelled with 125I, we have established the basic physicochemical parameters of the binding. A single receptor was found with a K(d) of 1 x 10-9 M. The number of receptors per cell was 3000-4000 and its molecular weight, as determined by cross-linking experiments, is 87 000. The binding of IFN-γ to its oligodendrocyte receptor is saturable, specific and temperature-dependent. The receptor-IFN-γ complex is quickly endocytosed at 37° (the half-time of maximal internalization is around 1 min). Some cytokines, such as interleukin-1α and interleukin-6, up-regulated the expression of the oligodendrocyte receptor, but others, such as tumour necrosis factor-α, did not. A dramatic increase in receptor expression is induced by lipopolysaccharide but it is not detectable after treatment with concanavalin A. | - |
dc.language.iso | eng | - |
dc.publisher | Blackwell Publishing | - |
dc.rights | closedAccess | - |
dc.title | Expression of interferon-γ receptors on murine oligodendrocytes and its regulation by cytokines and mitogens | - |
dc.type | artículo | - |
dc.date.updated | 2013-02-27T12:41:16Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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