English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/67463
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Epithelial organisation revealed by a network of cellular contacts

AuthorsEscudero, Luis M. ; Costa, Luciano da F.; Kicheva, Anna.; Briscoe, James; Freeman, Matthew; Babu, Madan
Issue Date2011
PublisherNature Publishing Group
CitationNature Communications 2: article number 526 (2011)
AbstractThe emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. Here we apply network theory at the scale of individual cells to uncover patterns in cell-to-cell contacts that govern epithelial organisation. We provide an objective characterisation of epithelia using network representation, where cells are nodes and cell contacts are links. The features of individual cells, together with attributes of the cellular network, produce a defining signature that distinguishes epithelia from different organs, species, developmental stages and genetic conditions. The approach permits characterization, quantification and classification of normal and perturbed epithelia, and establishes a framework for understanding molecular mechanisms that underpin the architecture of complex tissues. © 2011 Macmillan Publishers Limited. All rights reserved.
Publisher version (URL)http://dx.doi.org/10.1038/ncomms1536
URIhttp://hdl.handle.net/10261/67463
DOI10.1038/ncomms1536
E-ISSN2041-1723
Identifiersdoi: 10.1038/ncomms1536
issn: 2041-1723
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
epithelial_organisation_Escudero.pdf4,23 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.