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dc.contributor.authorAguado, Fernando-
dc.contributor.authorFernández, T.-
dc.contributor.authorMartínez-Murillo, Ricardo-
dc.contributor.authorRodrigo García, José-
dc.contributor.authorCacicedo, L.-
dc.contributor.authorSánchez-Franco, Franco-
dc.date.accessioned2013-02-21T10:10:50Z-
dc.date.available2013-02-21T10:10:50Z-
dc.date.issued1992-
dc.identifier.citationNeuroendocrinology 56: 856- 863 (1992)-
dc.identifier.issn0028-3835-
dc.identifier.urihttp://hdl.handle.net/10261/67138-
dc.description.abstractInsulin-like growth factor I (IGF-I) is shown to be involved in the regulation of pituitary hormones. High IGF-I concentrations were detected in hypothalamus and pituitary during adulthood. This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures. IGF-I was found to be widely distributed throughout the hypothalamus; it was present in the magnocellular neurons of the supraoptic, paraventricular, and accessory nuclei. Moreover, nerve fibres and puncta containing immunoreactive IGF-I were localized in the median eminence and the posterior lobe of the pituitary. These results support possible IGF-I neuromodulatory or neurohormonal action in the hypothalamus on pituitary hormone regulation.-
dc.language.isoeng-
dc.publisherS. Karger AG-
dc.rightsclosedAccess-
dc.titleImmunocytochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1159/000126317-
dc.date.updated2013-02-21T10:10:51Z-
dc.description.versionPeer Reviewed-
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