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Climbing fiber deafferentation reduces insulin-like growth factor I (IGF-I) content in cerebellum

AuthorsTorres Alemán, Ignacio ; Pons, Sebastián ; García-Segura, Luis M.
Issue Date1991
CitationBrain Research 564: 348- 351 (1991)
AbstractThe presence of insulin-like growth factor I (IGF-I) and its mRNA in adult rat cerebellum has recently been documented. Previous immunocytochemical studies showed prominent IGF-I-like staining in fibers around Purkinje cell somas. To determine the origin of this IGF-I input to the Purkinje cell we destroyed the inferior olivary complex by either 3-acetylpiridine administration or electrolytical lesions. In both types of lesions we found a similar significant depletion of IGF-I levels in cerebellum (40-50% of controls). No changes were found in cerebellar IGF-I receptors. These results suggest that almost half of the IGF-I content in cerebellum is provided by climbing fiber afferents arising from the inferior olivary complex.
Publisher version (URL)http://dx.doi.org/10.1016/0006-8993(91)91476-H
Identifiersdoi: 10.1016/0006-8993(91)91476-H
issn: 0006-8993
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