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Title

P53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

AuthorsArias-López, Carmen; Lázaro, Icíar; Kerr, Peter; Lord, Christopher J.; Dexter, Tim; Iravani, Marjan; Ashworth, Alan; Silva, Augusto
Keywordsp53
Rad51
transcriptional repression
homologous recombination
genome stability
Issue Date2006
PublisherNature Publishing Group
CitationEMBO reports 7(2):219-224(2006)
AbstractDNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulation of Rad51 messenger RNA and protein by wild-type p53, favoured by DNA damage. Moreover, wild-type p53 inhibits Rad51 foci formation in response to double-strand breaks, whereas p53 contact mutant R280K fails to repress Rad51 mRNA and protein expression and Rad51 foci formation. We propose that transcriptional repression of Rad51 by p53 participates in regulating homologous recombination, and impaired Rad51 repression by p53 mutants may contribute to malignant transformation
Description6 páginas, 4 figuras -- PAGS nros. 219-224
Publisher version (URL)http://dx.doi.org/10.1038/sj.embor.7400587
URIhttp://hdl.handle.net/10261/66584
DOI10.1038/sj.embor.7400587
ISSN1469-221X
E-ISSN1469-3178
Appears in Collections:(CIB) Artículos
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