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| Título: | Double bolt regulation of Rad51 by p53: a role for transcriptional repression |
Autor: | Lázaro, Icíar; Arias, Carmen; Silva, Augusto CSIC | Palabras clave: | p53 Rad51 homologous recombinations transcriptional repression Genome integrity |
Fecha de publicación: | 15-may-2006 | Editor: | Landes Bioscience | Citación: | Cell Cycle 5(10):1062-1065(2006) | Resumen: | The regulation of homologous recombination (HR) by p53 has been currently associated with its non-transactivating function; now the transcriptional repression of the Rad51 gene by p53 has been elucidated. This extra control by p53 involves the transcriptional down-regulation of Rad51 protein, which in turn accounts for the reduction of functional Rad51 foci. Down regulation of Rad51 protein might be relevant, considering that Rad51 is a rate-limiting factor in HR. Moreover, impaired Rad51-repression by p53 mutant proteins may contribute to malignant transformation | Descripción: | 4 páginas, 2 figuras -- PAGS nros. 1062-1065 | URI: | http://hdl.handle.net/10261/66579 | DOI: | 10.4161/cc.5.10.2764 | ISSN: | 1538-4101 | E-ISSN: | 1551-4005 |
| Aparece en las colecciones: | (CIB) Artículos |
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