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Double bolt regulation of Rad51 by p53: a role for transcriptional repression

AuthorsLázaro, Icíar; Arias, Carmen ; Silva, Augusto
homologous recombinations
transcriptional repression
genome integrity
Issue Date15-May-2006
PublisherLandes Bioscience
CitationCell Cycle 5(10):1062-1065(2006)
AbstractThe regulation of homologous recombination (HR) by p53 has been currently associated with its non-transactivating function; now the transcriptional repression of the Rad51 gene by p53 has been elucidated. This extra control by p53 involves the transcriptional down-regulation of Rad51 protein, which in turn accounts for the reduction of functional Rad51 foci. Down regulation of Rad51 protein might be relevant, considering that Rad51 is a rate-limiting factor in HR. Moreover, impaired Rad51-repression by p53 mutant proteins may contribute to malignant transformation
Description4 páginas, 2 figuras -- PAGS nros. 1062-1065
Appears in Collections:(CIB) Artículos
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