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Title

HBP2: A new mammalian protein that complements the fission yeast MBF transcription complex

AuthorsSánchez-Díaz, Alberto ; Blanco, Miguel A.; Moreno, Sergio
Issue Date2001
PublisherSpringer
CitationCurrent Genetics 40(2): 110-118 (2001)
AbstractThe mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates Cdc10-dependent transcription at G1/S and allows growth of cdc10-129, res1 Δ and rep2 Δ mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.
URIhttp://hdl.handle.net/10261/66564
DOI10.1007/s002940100241
Identifiersdoi: 10.1007/s002940100241
issn: 0172-8083
e-issn: 1432-0983
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