English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/66561
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Genomic specification and epigenetic regulation of eukaryotic DNA replication origins

AuthorsAntequera, Francisco
Issue Date2004
PublisherNature Publishing Group
CitationEMBO Journal 23(22): 4365-4370 (2004)
AbstractIdentification of DNA replication origins (ORIs) at a genome-wide level in eukaryotes has proved to be difficult due to the high degree of degeneracy of their sequences. Recent structural and functional approaches, however, have circumvented this limitation and have provided reliable predictions of their genomic distribution in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, and they have also significantly increased the number of characterized ORIs in animals. This article reviews recent evidence on how ORIs are specified and maintained in these systems and on their regulation and sensitivity to epigenetic signals. It also discusses the possible additional involvement of ORIs in processes other than DNA replication.
Identifiersdoi: 10.1038/sj.emboj.7600450
issn: 0261-4189
e-issn: 1460-2075
Appears in Collections:(IMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.