English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/66361
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase

AuthorsRodrigues-Poveda, C. A.; González-Pacanowska, D.; Szajnman, S. H.; Rodríguez, J. B.
Issue Date2012
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 56: 4483- 4486 (2012)
AbstractAs part of our efforts aimed at searching for new antiparasitic agents, the effect of representative 2-alkylaminoethyl-1,1-bisphosphonic acids on Trypanosoma cruzi squalene synthase (TcSQS) was investigated. These compounds had proven to be potent inhibitors of T. cruzi. This cellular activity had been associated with an inhibition of the enzymatic activity of T. cruzi farnesyl diphosphate synthase. 2-Alkylaminoethyl-1,1-bisphosphonic acids appear to have a dual action, since they also inhibit TcSQS at the nanomolar range. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
URIhttp://hdl.handle.net/10261/66361
DOI10.1128/AAC.00796-12
Identifiersdoi: 10.1128/AAC.00796-12
issn: 0066-4804
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.