English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/66310
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Is spreading depolarization characterized by an abrupt, massive release of gibbs free energy from the human brain cortex?

AuthorsDreier, J. P.; Isele, T.; Reiffurth, Clemens; Offenhauser, Nikolas; Kirov, S. A.; Dahlem, M. A.; Herreras, Óscar
Issue Date2013
PublisherSage Publications
CitationThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 19: 25- 42 (2013)
AbstractIn the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs-Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The authors propose that the ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death. © The Author(s) 2013.
URIhttp://hdl.handle.net/10261/66310
DOI10.1177/1073858412453340
Identifiersdoi: 10.1177/1073858412453340
issn: 1073-8584
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.