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Title

The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

AuthorsAlonso-Monge, Rebeca; Carvaihlo, Sara; Nombela, César; Rial, Eduardo ; Pla, Jesús
KeywordsAOX
Alternative oxidase carboxy
carboxy-2′7′-dichlorodihydrofluoresceinDNP2
4-dinitrophenolFCCP
carbonylcyanide p-trifluoromethoxyphenylhydrazoneHEt
dihydroethidiumMAPK
mitogen-activated protein kinaseMCLA
2-methyl-6-(4-methoxyphenyl)-3
dihydroimidazol[1,2-α] pyrazin-3-one
hydrochloridePQ
paraquatRh123
rhodamine 123ROS
reactive oxygen speciesSHAM
salicylhydroxamic acid
Issue DateFeb-2009
PublisherSociety for General Microbiology
CitationMicrobiology 155 (2) : 413-23 (2009)
AbstractSignal transduction pathways mediated by mitogen-activated protein kinases (MAPKs) play crucial roles in eukaryotic cells. In the pathogenic fungus Candida albicans the HOG MAPK pathway regulates the response to external stresses (osmotic and oxidative among others) and is involved in morphogenesis and virulence. We show here that the lack of the Hog1 MAPK increases the sensitivity of this fungus to inhibitors of the respiratory chain. hog1 mutants also show an enhanced basal respiratory rate compared to parental strains, and higher levels of intracellular reactive oxygen species despite an increased expression of detoxifying enzymes. We also demonstrate that although oxidative phosphorylation is essentially unaffected, hog1 mutants have an altered mitochondrial membrane potential. Data indicate that hog1-defective mutants are more dependent on mitochondrial ATP synthesis, probably due to an increased cellular ATP demand. Our results therefore link a MAPK pathway with respiratory metabolism in pathogenic fungi
Description11 páginas, 6 figuras, 2 tablas -- PAGS nros. 413-423
Publisher version (URL)http://dx.doi.org/10.1099/mic.0.023309-0
URIhttp://hdl.handle.net/10261/66254
DOI10.1099/mic.0.023309-0
ISSN1350-0872
E-ISSN1465-2080
Appears in Collections:(CIB) Artículos
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