English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/66138
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Pten positively regulates brown adipose function, energy expenditure, and longevity

AuthorsLopez-Guadamillas, Elena; Gómez-López, Gonzalo; Cañamero, Marta; Mulero, Francisca; González-Barroso, M. Mar ; Rial, Eduardo ; Valverde, Ángela M.; Serrano, Manuel
KeywordsAdipose tissue
Brown/metabolism
DNA-Binding Proteins/genetics/metabolism
Energy Metabolism/genetics/physiology
Ion Channels/genetics/metabolism
Issue Date7-Mar-2012
PublisherElsevier
CitationCell Metabolism 15(3):382–394(2012)
AbstractAging in worms and flies is regulated by the PI3K/Akt/Foxo pathway. Here we extend this paradigm to mammals. Ptentg mice carrying additional genomic copies of Pten are protected from cancer and present a significant extension of life span that is independent of their lower cancer incidence. Interestingly, Ptentg mice have an increased energy expenditure and protection from metabolic pathologies. The brown adipose tissue (BAT) of Ptentg mice is hyperactive and presents high levels of the uncoupling protein Ucp1, which we show is a target of Foxo1. Importantly, a synthetic PI3K inhibitor also increases energy expenditure and hyperactivates the BAT in mice. These effects can be recapitulated in isolated brown adipocytes and, moreover, implants of Ptentg fibroblasts programmed with Prdm16 and Cebpβ form subcutaneous brown adipose pads more efficiently than wild-type fibroblasts. These observations uncover a role of Pten in promoting energy expenditure, thus decreasing nutrient storage and its associated damage
Description13 páginas, 7 figuras, 7 figuras suplementarias, 7 tablas suplementarias.-- et al.
Publisher version (URL)http://dx.doi.org/10.1016/j.cmet.2012.02.001
URIhttp://hdl.handle.net/10261/66138
DOI10.1016/j.cmet.2012.02.001
ISSN1550-4131
E-ISSN1932-7420
Appears in Collections:(CIB) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdf21,67 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.