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ATP and adenylate energy charge during phosphate-mediated control of antibiotic synthesis

AuthorsMartín, Juan F.; Liras, Paloma; Demain, Arnold L.
Issue Date1978
CitationBiochemical and Biophysical Research Communications 83(3): 822-828 (1978)
AbstractThe addition of inorganic phosphate or guanosine-5′-monophosphate to a phosphate-limited mycelial system of Streptomyces griseus inhibited candicidin production. Accompanying the inhibition was a rapid increase in intracellular ATP concentration. Adenylate energy charge increased only slightly indicating that ATP is a more likely intracellular effector than energy charge in mediating phosphate control of antibiotic biosynthesis.
Identifiersdoi: 10.1016/0006-291X(78)91468-7
issn: 0006-291X
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