Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/65458
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Choice of calcineurin inhibitor may influence the development of de novo immune hepatitis associated with anti-GSTT1 antibodies after liver transplantation

AutorAguilera, Isabel CSIC ORCID; Sousa, José M.; Praena-Fernández, Juan Manuel; Gómez-Bravo, Miguel A. CSIC ORCID; Núñez-Roldán, Antonio CSIC ORCID
Fecha de publicación2011
EditorBlackwell Publishing
CitaciónClinical Transplantation 25(2): 207-212 (2011)
ResumenIn 2004, we defined the genetic mismatch in the glutathione S-transferase T1 (GSTT1) gene positive donor/null recipient as a risk factor to develop de novo immune hepatitis (IH) after liver transplant (LT), which is always associated with production of donor-specific anti-GSTT1 antibodies. However, there are several unresolved questions, such as why some of these patients produce antibodies, why others do not and why not all of the patients with antibodies develop the disease. The aim of this study was to evaluate the influence of several variables in the production of anti-GSTT1 antibodies and/or de novo IH. The study group included 35 liver-transplanted patients. The number of patients not producing antibodies was significantly higher in the group treated with Tac-based immunosuppression compared with the CsA-based group (94.1% vs. 5.9%, p=0.001). Additionally, a protective effect of the Tac-based therapy vs. the CsA-based therapy was observed with regard to development of de novo IH (80.8% vs. 19.2%, p=0.003). In conclusion, the choice of calcineurin inhibitor may influence the development of de novo IH mediated by anti-GSTT1 antibodies. © 2010 John Wiley & Sons A/S.
URIhttp://hdl.handle.net/10261/65458
DOI10.1111/j.1399-0012.2010.01221.x
Identificadoresdoi: 10.1111/j.1399-0012.2010.01221.x
issn: 0902-0063
Aparece en las colecciones: (IBIS) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

21
checked on 08-mar-2024

WEB OF SCIENCETM
Citations

17
checked on 24-feb-2024

Page view(s)

308
checked on 27-mar-2024

Download(s)

90
checked on 27-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.