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Title

Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells

AuthorsSánchez-Álvarez, Miguel; Sánchez-Hernández, Noemí; Suñé, Carlos
Issue Date2011
PublisherHindawi Publishing Corporation
CitationGenetics Research International 2011: 626081 (2011)
AbstractDuring the last 30 years, systematic biochemical and functional studies have significantly expanded our knowledge of the transcriptional molecular components and the pre-mRNA processing machinery of the cell. However, our current understanding of how these functions take place spatiotemporally within the highly compartmentalized eukaryotic nucleus remains limited. Moreover, it is increasingly clear that ¿the whole is more than the sum of its parts¿ and that an understanding of the dynamic coregulation of genes is essential for fully characterizing complex biological phenomena and underlying diseases. Recent technological advances in light microscopy in addition to novel cell and molecular biology approaches have led to the development of new tools, which are being used to address these questions and may contribute to achieving an integrated and global understanding of how the genome works at a cellular level. Here, we review major hallmarks and novel insights in RNA polymerase II activity and pre-mRNA processing in the context of nuclear organization, as well as new concepts and challenges arising from our ability to gather extensive dynamic information at the single-cell resolution.
Publisher version (URL)http://doi.org/10.4061/2011/626081
URIhttp://hdl.handle.net/10261/65448
DOI10.4061/2011/626081
Identifiersissn: 2090-3162
Appears in Collections:(IPBLN) Artículos
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