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Title

Characterization of Candida parapsilosis complex isolates

AuthorsToro Crespo, M. de; Torres, M. J.; Maite, Ruiz; Aznar Martín, Javier CSIC
Issue Date2011
PublisherBlackwell Publishing
CitationClinical Microbiology and Infection 17(3): 418-424 (2011)
AbstractCandida parapsilosis former groups II and III have recently been established as independent species, named Candida orthopsilosis and Candida metapsilosis, respectively. We investigated the distribution of C. parapsilosis complex species in 122 isolates from blood and other sources in a southern Spain tertiary-care hospital, and we examined the relationship between species, site of isolation and biofilm positivity. We also evaluated the planktonic MICs and sessile MICs (SMICs) of voriconazole, amphotericin B and anidulafungin. One hundred and eleven isolates (91%) were categorized as C. parapsilosis sensu stricto, whereas ten isolates (8.2%) were categorized as C. orthopsilosis and one (0.8%) as C. metapsilosis. Biofilm positivity was observed in 58.5% (65 of 111) of C. parapsilosis sensu stricto isolates vs. 0% (0 of 11) of C. orthopsilosis and C. metapsilosis isolates (p<0.01). There was no difference in biofilm production among C. parapsilosis sensu stricto isolates from blood and other sources. MIC values showed that all isolates were susceptible to voriconazole and amphotericin B, whereas two isolates (1.8%) of C. parapsilosis sensu stricto were non-susceptible to anidulafungin. However, the MIC 90 value of voriconazole was higher (0.125mg/L) for C. orthopsilosis than forC. parapsilosis sensu stricto (0.03mg/L). In contrast to planktonic cells, the SMICs show that amphotericin B and anidulafungin are moderately effective against the biofilm of C. parapsilosis sensu stricto, whereas voriconazole is ineffective. © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
URIhttp://hdl.handle.net/10261/65432
DOI10.1111/j.1469-0691.2010.03302.x
Identifiersdoi: 10.1111/j.1469-0691.2010.03302.x
issn: 1198-743X
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