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dc.contributor.authorMerino, Pedro-
dc.date.accessioned2013-01-29T09:36:56Z-
dc.date.available2013-01-29T09:36:56Z-
dc.date.issued2012-
dc.identifierdoi: 10.1002/cmdc.201200022-
dc.identifierissn: 1860-7179-
dc.identifiere-issn: 1860-7187-
dc.identifier.citationChemMedChem 7(4): 565-569 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/65350-
dc.description.abstractAffairs of the HAART! The synthesis of HEPT-derived, truncated reverse isoxazolidinyl nucleosides (shown) is reported. These compounds represent the first examples of isoxazolidines bearing a pyrimidine scaffold at the C-3 position using a glycoside-type linkage. Biological evaluation showed that some of the derivatives act as non-nucleoside inhibitors of HIV-1 reverse transcriptase, with an efficacy comparable to that of Nevirapine but with reduced toxicity.-
dc.description.sponsorshipThe authors gratefully acknowledge the Italian Ministry of Education, Universities, and Research (MIUR), the University of Messina (Italy), the University of Catania (Italy), and the Interuniversity Consortium for Innovative Methodologies and Processes for Synthesis (CINMPIS), the University of Milan–Bicocca (Italy) for partial financial support. -
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.rightsclosedAccess-
dc.titleTruncated reverse isoxazolidinyl nucleosides: A new class of allosteric HIV-1 reverse transcriptase inhibitors-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1002/cmdc.201200022-
dc.date.updated2013-01-29T09:36:56Z-
dc.description.versionPeer Reviewed-
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