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Title

Truncated reverse isoxazolidinyl nucleosides: A new class of allosteric HIV-1 reverse transcriptase inhibitors

AuthorsMerino, Pedro
Issue Date2012
PublisherWiley-VCH
CitationChemMedChem 7(4): 565-569 (2012)
AbstractAffairs of the HAART! The synthesis of HEPT-derived, truncated reverse isoxazolidinyl nucleosides (shown) is reported. These compounds represent the first examples of isoxazolidines bearing a pyrimidine scaffold at the C-3 position using a glycoside-type linkage. Biological evaluation showed that some of the derivatives act as non-nucleoside inhibitors of HIV-1 reverse transcriptase, with an efficacy comparable to that of Nevirapine but with reduced toxicity.
URIhttp://hdl.handle.net/10261/65350
DOI10.1002/cmdc.201200022
Identifiersdoi: 10.1002/cmdc.201200022
issn: 1860-7179
e-issn: 1860-7187
Appears in Collections:(ISQCH) Artículos
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