English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/65350
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | Truncated reverse isoxazolidinyl nucleosides: A new class of allosteric HIV-1 reverse transcriptase inhibitors |
Authors: | Merino, Pedro ![]() |
Issue Date: | 2012 |
Publisher: | Wiley-VCH |
Citation: | ChemMedChem 7(4): 565-569 (2012) |
Abstract: | Affairs of the HAART! The synthesis of HEPT-derived, truncated reverse isoxazolidinyl nucleosides (shown) is reported. These compounds represent the first examples of isoxazolidines bearing a pyrimidine scaffold at the C-3 position using a glycoside-type linkage. Biological evaluation showed that some of the derivatives act as non-nucleoside inhibitors of HIV-1 reverse transcriptase, with an efficacy comparable to that of Nevirapine but with reduced toxicity. |
URI: | http://hdl.handle.net/10261/65350 |
DOI: | 10.1002/cmdc.201200022 |
Identifiers: | doi: 10.1002/cmdc.201200022 issn: 1860-7179 e-issn: 1860-7187 |
Appears in Collections: | (ISQCH) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | ![]() View/Open |
Show full item record
Review this work
Review this work
Related articles:
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.