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Protection and antibody response induced by intramuscular DNA vaccine encoding for viral haemorrhagic septicaemia virus (VHSV) G glycoprotein in turbot (Scophthalmus maximus)

AuthorsPereiro, Patricia ; Martínez-López, Alicia; Falcó, Alberto; Dios, S. ; Figueras Huerta, Antonio ; Figueras Huerta, Antonio ; Coll, Julio; Novoa, Beatriz ; Estepa, Amparo
KeywordsDNA vaccine
Glycoprotein G
Issue Date2012
CitationFish and Shellfish Immunology 32(6): 1088-1096 (2012)
AbstractTurbot (Scophthalmus maximus) is a high-value farmed marine flatfish with growing demand and production levels in Europe susceptible to turbot-specific viral haemorrhagic septicaemia virus (VHSV) strains. To evaluate the possibility of controlling the outbreaks of this infectious disease by means of DNA vaccination, the gpG of a VHSV isolated from farmed turbot (VHSV860) was cloned into an expression plasmid containing the human cytomegalovirus (CMV) promoter (pMCV1.4-G860). In our experimental conditions, DNA immunised turbots were more than 85% protected against VHSV860 lethal challenge and showed both VHSV-gpG specific and neutralizing antibodies. To our knowledge this is the first report showing the efficacy of turbot genetic immunisation against a VHSV. Work is in progress to determine the contribution of innate and adaptive immunity to the protective response elicited by the immunization.
Description7 páginas, 5 figuras
Publisher version (URL)http://dx.doi.org/10.1016/j.fsi.2012.03.004
Appears in Collections:(IIM) Artículos
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