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Título: | Effects of Neospora caninum infection at mid-gestation on placenta in a pregnant mouse model |
Autor: | López Pérez, I. C.; Collantes Fernández, E.; Rojo Montejo, S.; Navarro Lozano, V.; Risco Castillo, V.; Pérez Pérez, Valentín CSIC ORCID ; Pereira Bueno, J. M.; Ortega Mora, Luis M. | Palabras clave: | BALB/c mice Immune-responses Vertical transmission Bovine neosporosis Toxoplasma-gondii Real-time Fetal survival Parasite load IFN-gamma Gestation |
Fecha de publicación: | 2010 | Editor: | American Society of Parasitologists | Citación: | Journal of Parasitology 96 (5) : 1017-1020 (2010) | Resumen: | Neospora caninum is one of the more-efficient transplacentally-transmitted organisms. The goal of the present study was to investigate the pathologic and immunologic changes that occur at the materno-fetal interphase in pregnant BALB/c mice infected with N. caninum at mid-gestation. Parasite DNA was detected in feto-placentary units 3 days post-infection (PI). On day 7 PI, the DNA detection level and parasite burden were significantly higher in the placentas than in the fetuses, which may indicate that the parasite is mainly multiplying in the placenta during the initial infection. In the spleens of infected dams, we observed an increase in IFN-gamma, IL-10, and IL-4. However, only IL-4 was upregulated in placentas from the infected dams; this may enhance susceptibility to N. caninum at the materno-fetal interphase and favor transmission to the progeny. Finally, an increase in TNF-alpha expression in nested-PCR-positive placentas combined with necrosis may compromise the viability of the fetuses. | Descripción: | 5 páginas, 3 figuras, 2 tablas. | Versión del editor: | http://dx.doi.org/10.1645/GE-2347.1 | URI: | http://hdl.handle.net/10261/64451 | DOI: | 10.1645/GE-2347.1 | ISSN: | 0022-3395 |
Aparece en las colecciones: | (IGM) Artículos |
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Perez-Perez, V. Journal of parasitology 2010.pdf | 122,1 kB | Adobe PDF | Visualizar/Abrir |
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