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Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product

AuthorsRamos-Morales, Francisco; Domínguez, África; Romero, Francisco; Luna, Rosa ; Multon, Marie-Christine; Pintor-Toro, José Antonio
Issue Date2000
PublisherNature Publishing Group
CitationOncogene 19(3): 403-409 (2000)
AbstractWe recently isolated a cDNA for hpttg, the human homolog of rat pituitary tumor transforming gene. Now we have analysed the expression of hpttg as a function of cell proliferation. hPTTG protein level is up-regulated in rapidly proliferating cells, is down-regulated in response to serum starvation or cell confluence, and is regulated in a cell cycle-dependent manner, peaking in mitosis. In addition, we show that hPTTG is phosphorylated during mitosis. Immunodepletion and in vitro phosphorylation experiments, together with the use of a specific inhibitor, indicate that Cdc2 is the kinase that phosphorylates hPTTG. These results suggest that hpttg is induced by and may have a role in, regulatory pathways involved in the control of cell proliferation.
Identifiersissn: 0950-9232
e-issn: 1476-5594
Appears in Collections:(IRNAS) Artículos
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