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Synthesis and biological evaluation of indazole derivatives

AuthorsClaramunt, Rosa M.; López, C.; Pérez-Medina, Carlos; Pérez-Torralba, M.; Alkorta, Ibon ; Elguero, José ; Escames, G.; Acuña-Castroviejo, D.
Issue Date2011
CitationEuropean Journal of Medicinal Chemistry 46: 1439- 1447 (2011)
AbstractThe inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, Erel, between stacking and apical interaction energies of indazoles with the active site of the NOS enzyme has been established. © 2011 Elsevier Masson SAS. All rights reserved.
Publisher version (URL)http://dx.doi.org/10.1016/j.ejmech.2011.01.027
Identifiersdoi: 10.1016/j.ejmech.2011.01.027
issn: 0223-5234
Appears in Collections:(IQM) Artículos
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