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Characterization and regulation of enzymes involved in Cephamycin C biosynthesis in Streptomyces lactamdurans

AuthorsLiras Padín, P.; Laiz Trobajo, L. ; Castro González, José Mª; Cortés, Jesús ; Martín Martín, Juan Fco.
Issue Date1988
PublisherNational Technical Information Centre and Library (Hungary)
CitationMicrobial physiology and manufacturing industry. Working parties of applied biocatalysis and microbial physiology: 124-132 (1988)
AbstractSeveral enzymes of the biosynthesis of beta-lactam antibiotics both in fungi and Streptomyces have been purified (l) and some of the genes coding for these enzymes have been recently cloned (2-4). We have been involved for several years in the study of the biosynthetic pathway of cephamycin C in Streptomyces lactamdurans. The aim of our work is: 1) to purify the enzymes for the biosynthesis of cephamycin in S. lactamdurans and to compare them with similar enzymes in other, beta-lactam producing organisms; 21) to characterize the regulatory mechanisms that are exerted on the biosynthesis of cephamycin C in this microorganism; 3) to clone the genes involved in order to characterize better this regulation at the molecular level. Enzymes
Description9 pages, 4 figures, 1 table, 15 references. Proceedings of Fourth International Workshop. Hajdúszoboszló, 27-29, april, 1988. Budapest, Hungary.
Appears in Collections:(IRNAS) Libros y partes de libros
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