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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/64228
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dc.contributor.authorQuesada-García, Alba-
dc.contributor.authorLeal, Esther-
dc.contributor.authorSánchez Martínez, Elisa-
dc.contributor.authorMartín-Belinchón, Mónica-
dc.contributor.authorCerdá-Reverter, José Miguel-
dc.date.accessioned2013-01-16T12:30:28Z-
dc.date.available2013-01-16T12:30:28Z-
dc.date.issued2012-
dc.identifierdoi: 10.1016/j.aquaculture.2012.02.010-
dc.identifierissn: 0044-8486-
dc.identifier.citationAquaculture 338-341: 172-180 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/64228-
dc.description9 páginas, 6 figuras, 1 tabla.-- et al.-
dc.description.abstractNormal functioning of the endocrine system is essential for the proper development and reproduction of animals. Substances interfering with its homeostasis are called endocrine disruptors (EDs) and may represent a risk for the health of the organism. One of the mechanisms of endocrine disruption that has attracted great attention in recent years concerns alterations in the normal functioning of the estrogen receptor (ER), but far less attention has been paid to those substances interfering with the thyroid axis, which, in fish, plays several critical roles in a variety of biological functions. In aquaculture, feedstuffs can be a source of hormones or persistent pollutants which act as potential EDs. In this study, the main purpose was to assess the possible estrogenic and thyrogenic activities of 32 commercial fish feeds. For the assessment of estrogenicity, a new estrogen receptor specific reporter gene assay using sea bass ERα (sbER α) was developed and validated. Potential thyroidal disruption was screened with a cell line permanently transfected with luciferase as reporter gene under the control of avian thyroid receptor α (THRα). The results obtained showed that 11 and 18 out of 32 assayed feeds were able to activate the sbERα or the avTHRα1, respectively. The present study is pioneer in demonstrating thyrogenic activity in fish diets commercially available and widely used in aquaculture. Given that maintaining the homeostasis in the endocrine system is critical for the proper development and reproduction of fish, any estrogenic or thyrogenic activity caused by the feedstuffs should be taken into account with regards to its potential impact on farmed fish. © 2012 Elsevier B.V.-
dc.description.sponsorshipThis study was funded by projects RTA 2009-00074-00-00 (MICINN) managed by the INIA, AGL 2010-22247-C03-01 and CSD 2007-00002 managed by IATS-CSIC from the Spanish Ministry of Science and Innovation.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsopenAccess-
dc.titleAssessment of estrogenic and thyrogenic activities in fish feeds-
dc.typeartículo-
dc.identifier.doi10.1016/j.aquaculture.2012.02.010-
dc.date.updated2013-01-16T12:30:28Z-
dc.description.versionPeer Reviewed-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeartículo-
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