Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/64152
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invite to open peer review
Title

Breast-feeding modulates the influence of the peroxisome proliferator-activated receptor-γ (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study

AuthorsVérier, C.; Meirhaeghe, Aline; Bokor, S.; Breidenassel, Christina; Manios, Yannis; Molnár, Dénes; Artero, Enrique G.; Nova, Esther CSIC ORCID ; De Henauw, Stefaan; Moreno, Luis A.; Amouyel, Philippe; Labayen, Idoia; Bevilacqua, N.; Turck, D.; Béghin, Laurent; Dallongeville, Jean; Gottrand, Frederic
Issue Date2010
PublisherAmerican Diabetes Association
CitationDiabetes Care 33: 190- 196 (2010)
AbstractOBJECTIVE - The peroxisome proliferator-activated receptor-γ2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations. RESEARCH DESIGN AND METHODS - Data on breast-feeding duration, BMI, and genotypes for the Pro12Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses. RESULTS - No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P<0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e.g., Δ BMI +1.88 kg/m2, adjusted for age, sex, and center, P=0.007) than Pro12Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Ala12 allele carriers and Pro12Pro children in terms of adiposity measurements, whatever the duration of breast-feeding. CONCLUSIONS - Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents. © 2010 by the American Diabetes Association.
URIhttp://hdl.handle.net/10261/64152
DOI10.2337/dc09-1459
Identifiersdoi: 10.2337/dc09-1459
issn: 0149-5992
Appears in Collections:(ICTAN) Artículos




Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record

CORE Recommender

PubMed Central
Citations

11
checked on May 8, 2024

SCOPUSTM   
Citations

25
checked on May 17, 2024

WEB OF SCIENCETM
Citations

20
checked on Feb 25, 2024

Page view(s)

357
checked on May 22, 2024

Download(s)

85
checked on May 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.