English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/63836
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Modification of the TRX2 gene dose in Saccharomyces cerevisiae affects hexokinase 2 gene regulation during wine yeast biomass production

AuthorsGómez Pastor, Rocío ; Pérez Torrado, Roberto ; Matallana, Emilia
Issue Date2012
PublisherSpringer
CitationApplied Microbiology and Biotechnology 94: 773- 787 (2012)
AbstractIn the industrial yeast biomass production process, cells undergo an oxidative and other stresses which worsen the quality of the produced biomass. The overexpression of the thioredoxin codifying gene TRX2 in a wine Saccharomyces cerevisiae strain increases resistance to oxidative stress and industrial biomass production yield. We observed that variations in the TRX2 gene dose in wine yeast strains are relevant to determine the fermentative capacity throughout the industrial biomass production process. So, we studied the molecular changes using a transcriptomic approach under these conditions. The results provide an overview of the different metabolic pathways affected during industrial biomass production by TRX2 gene manipulation. The oxidative stress-related genes, like those related with the glutathione metabolism, presented outstanding variations. The data also allowed us to propose new thioredoxin targets in S. cerevisiae, such as hexokinase 2, with relevance for industrial fermentation performance. © Springer-Verlag 2011.
URIhttp://hdl.handle.net/10261/63836
DOI10.1007/s00253-011-3738-9
Identifiersdoi: 10.1007/s00253-011-3738-9
issn: 0175-7598
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
Gomez PAstor-AMB 2012.pdf888,1 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.