English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/63714
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

AuthorsCaloca, María J. ; Zugaza, José L.; Matallanas, David; Crespo, Piero ; Bustelo, Xosé R.
Issue Date2003
PublisherNature Publishing Group
CitationEMBO Journal 22(13): 3326-3336 (2003)
AbstractHere we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction is crucial for Ras activation in lymphoid cells, since this GTPase cannot become activated in the absence of Vav proteins. The activation of RasGRP1 requires both the generation of diacylglycerol via phospholipase C-γ and the induction of actin polymerization, two responses induced by Vav and Rac1 that facilitate the translocation of RasGRP1 to juxtamembrane areas of the cell. Consistent with this, the cross-talk can be activated by tyrosine-phosphorylated wild-type Vav, oncogenic Vav and constitutively active Rac1. Conversely, Ras activation can be blocked in lymphocytes and ectopic systems using inhibitors affecting either phospholipase C-γ or F-actin polymerization. These results indicate that a relay mechanism exists in lymphoid and other cells helping in the generation of robust signaling responses by the Rac/Rho and Ras pathways upon receptor engagement.
URIhttp://hdl.handle.net/10261/63714
DOI10.1093/emboj/cdg316
Identifiersdoi: 10.1093/emboj/cdg316
issn: 0261-4189
e-issn: 1460-2075
Appears in Collections:(IBMCC) Artículos
(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.