English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/63480
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-Β-catenin pathway

AuthorsMartínez-Morales, Patricia L. ; Quiroga, Alejandra C. ; Barbas, Julio A. ; Morales, Aixa V.
Issue Date2010
PublisherNature Publishing Group
CitationEMBO Reports 11: 466- 472 (2010)
AbstractGenes of the SOX family of high-mobility group transcription factors are essential during nervous system development. In this study, we show that SOX5 is expressed by neural progenitors in the chick spinal cord and is turned off as differentiation proceeds. The overexpression of SOX5 in neural progenitors causes premature cell cycle exit and prevents terminal differentiation. Conversely, knocking down SOX5 protein extends the proliferative period of neural progenitors and causes marked cell death in a dorsal interneuron (dI3) population. Furthermore, SOX5 reduces WNT-Β-catenin signalling, thereby triggering the expression of the negative regulator of the pathway axin2. We propose that SOX5 regulates the timing of cell cycle exit by opposing WNT-Β-catenin activity on cell cycle progression. © 2010 EUROPEEAN MoleEcular Biology Oorganization.
Identifiersdoi: 10.1038/embor.2010.61
issn: 1469-221X
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
Sox5_Wnt_EMBOreports_Morales_AV.pdf8,41 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.