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| Título: | Cyclopropanation reactions for the synthesis of 2-azabieyclo[4.1.0]heptane derivatives with nitric oxide synthase inhibitory activity |
Autor: | Villar, Irene S. del; Gradillas, Ana; Gómez-Ovalies, A.; Martínez-Murillo, Ricardo CSIC ORCID; Martínez, Alfredo CSIC ORCID; Pérez-Castells, Javier | Fecha de publicación: | 2008 | Editor: | Chemical Society of Japan | Citación: | Chemistry Letters 37: 1222- 1223 (2008) | Resumen: | Synthesis of new bicyclic structures containing cyclopro-panes, related to selective iNOS inhibitor ONO-1714, is described. We have evaluated the effect of the compounds obtained on the production of nitric oxide in lipopolysaccharide and inter-feron-gamma stimulated mouse peritoneal macrophages and on in vitro iNOS activity assays. Copyright © 2008 The Chemical Society of Japan. | URI: | http://hdl.handle.net/10261/63426 | DOI: | 10.1246/cl.2008.1222 | Identificadores: | doi: 10.1246/cl.2008.1222 issn: 0366-7022 |
| Aparece en las colecciones: | (IC) Artículos |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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