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Título

Podocalyxin enhances the adherence of cells to platelets

AutorLarrucea, Susana ; Butta, Nora ; Rodríguez, Ramón B.; Alonso, Sonia ; García Arias-Salgado, Elena ; Sánchez Ayuso, Matilde ; Parrilla, Roberto L.
Palabras clavePodocalyxin
Platelets
Adhesion
Aggregation
Tera-1
Fecha de publicación8-oct-2007
EditorSpringer
CitaciónCell Mol Life Sci. 64(22):2965-2974(2007)
ResumenPodocalyxin (PODXL) is a mucin protein of the CD34 family expressed in kidney glomerular podocytes, vascular endothelium, progenitor bone marrow and tumor cells. It is assumed that PODXL plays an anti-adherent role in kidney podocytes. CHO cells stably expressing human PODXL (CHO-PODXL) or human tumor cells (Tera-1) inherently expressing PODXL showed increased adherence to platelets. The adherence of cells was inhibited (70%) by blockers of platelet P-selectin, prevented by the soluble ectodomain of human PODXL (PODXL-Δ) or by the arginine-glycine-aspartate (RGDS) peptide and partially impeded by inhibition of integrin αVβ3/αVβ5, suggesting a coordinated action of P-selectin and integrins. Colocalization of platelet P-selectin and PODXL expressed on CHO cells was demonstrated by confocal immunofluorescence. No adherence to platelets was observed when PODXL was expressed in glycomutant CHO cells deficient in sialic acid.
Descripción10 pages.
Versión del editorhttp://dx.doi.org/10.1007/s00018-007-7374-6
URIhttp://hdl.handle.net/10261/6339
DOI10.1007/s00018-007-7374-6
ISSN1420-682X (Print)
1420-9071 (Online)
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