English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/6339
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 12 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Podocalyxin enhances the adherence of cells to platelets
Autor : Larrucea, Susana ; Butta, Nora ; Rodríguez, Ramón B.; Alonso, Sonia ; García Arias-Salgado, Elena ; Sánchez Ayuso, Matilde ; Parrilla, Roberto L.
Palabras clave : Podocalyxin
Platelets
Adhesion
Aggregation
Tera-1
Fecha de publicación : 8-oct-2007
Editor: Springer
Citación : Cell Mol Life Sci. 64(22):2965-2974(2007)
Resumen: Podocalyxin (PODXL) is a mucin protein of the CD34 family expressed in kidney glomerular podocytes, vascular endothelium, progenitor bone marrow and tumor cells. It is assumed that PODXL plays an anti-adherent role in kidney podocytes. CHO cells stably expressing human PODXL (CHO-PODXL) or human tumor cells (Tera-1) inherently expressing PODXL showed increased adherence to platelets. The adherence of cells was inhibited (70%) by blockers of platelet P-selectin, prevented by the soluble ectodomain of human PODXL (PODXL-Δ) or by the arginine-glycine-aspartate (RGDS) peptide and partially impeded by inhibition of integrin αVβ3/αVβ5, suggesting a coordinated action of P-selectin and integrins. Colocalization of platelet P-selectin and PODXL expressed on CHO cells was demonstrated by confocal immunofluorescence. No adherence to platelets was observed when PODXL was expressed in glycomutant CHO cells deficient in sialic acid.
Descripción : 10 pages.
Versión del editor: http://dx.doi.org/10.1007/s00018-007-7374-6
URI : http://hdl.handle.net/10261/6339
DOI: 10.1007/s00018-007-7374-6
ISSN: 1420-682X (Print)
1420-9071 (Online)
Aparece en las colecciones: (CIB) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.